Cytoplasmic pH regulation and chloride/bicarbonate exchange in avian osteoclasts.
نویسندگان
چکیده
منابع مشابه
Cytoplasmic pH regulation and chloride/bicarbonate exchange in avian osteoclasts.
Osteoclasts resorb bone by first attaching to the bone surface and then secreting protons into an isolated extracellular compartment formed at the cell-bone attachment site. This secretion of protons (local acidification) is required to solubilize bone hydroxyapatite crystals and for activity of bone collagen-degrading acid proteases. However, the large quantity of protons required, 2 mol/mol o...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1989
ISSN: 0021-9738
DOI: 10.1172/jci113863